Noah W. Palm1, 2Rachel K. Rosenstein1, 2 Ruslan Medzhitov1
Affiliations/Contributions/Correspondingauthor
Nature 484, 465–472 (26 April 2012)doi:10.1038/nature11047 Published online 25 April 2012
Allergies are generally thought to be adetrimental outcome of a mistargeted immune response that evolved to provideimmunity to macroparasites. Here we present arguments to suggest that allergicimmunity has an important role in host defence against noxious environmentalsubstances, including venoms, haematophagous fluids, environmental xenobioticsand irritants. We argue that appropriately targetedallergic reactions are beneficial, although they can become detrimental whenexcessive. Furthermore, we suggest thatallergic hypersensitivity evolved to elicit anticipatory responses and topromote avoidance of suboptimal environments. 部落格設置目的:
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