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專業參考區:
In palmar hyperhidrosis, 50 subepidermal injections of 2 mouse unitsper palm (total 100 mouse units per palm) results in anhydrosis lasting4-12 months. Each injection produces an area of anhydrosisapproximately 1.2 cm in diameter. The only adverse effect is mildtransient thumb weakness that resolves within 3 weeks. Adverse effectsof intradermal injections of botulinum A toxin may result fromdiffusion into underlying muscles.
手汗症,每邊打100U的肉毒桿菌,可維持4-12個月。每個入針點可造成1.2公分的「無汗區」。唯一的副作用是暫時性的拇指麻木,但通常三個星期內會好,還有就是打太深會使藥品擴散到更深層的肌肉。
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參考文獻
Shelley WB, Talanin NY, Shelley ED. Botulinum toxin therapy for palmar hyperhidrosis. J Am Acad Dermatol. Feb 1998;38(2 Pt 1):227-9. [Medline].
Swartling C, Farnstrand C, Abt G, Stalberg E, Naver H. Side-effectsof intradermal injections of botulinum A toxin in the treatment ofpalmar hyperhidrosis: a neurophysiological study. Eur J Neurol. Sep 2001;8(5):451-6. [Medline].
In a similar study, the effects of sodium chloride solutioninjections in one palm were compared with botulinum toxin injections inthe other palm. Treatment with 120 mouse units of botulinum toxin(injected into 6 sites in the palm) resulted in a 26% reduction insweat production after 3 and 8 weeks and a 31% reduction after 13weeks. Noted adverse effects included minor muscle weakness at thetoxin-treated sites, which resolved after 2-5 weeks. Injections ofbotulinum toxin must be repeated at varying intervals to maintainlong-term results.
Schnider P, Binder M, Auff E, Kittler H, Berger T, Wolff K.Double-blind trial of botulinum A toxin for the treatment of focalhyperhidrosis of the palms. Br J Dermatol. Apr 1997;136(4):548-52.[Medline].
# Treatment of axillary hyperhidrosis with botulinum toxin type Areconstituted in lidocaine or in normal saline was described in arandomized, side-by-side, double-blind study. The results were thesame; however, injections of botulinum toxin A reconstituted inlidocaine are associated with significantly reduced pain, thus,lidocaine-reconstituted botulinum toxin A may be preferable fortreating axillary hyperhidrosis.
腋下多汗的治療上,肉毒桿菌可加入局部麻醉藥品lidocaine稀釋,注射時的疼痛感將可大大的減低。
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參考文獻
Vadoud-Seyedi J, Simonart T. Treatment of axillary hyperhidrosiswith botulinum toxin type A reconstituted in lidocaine or in normalsaline: a randomized, side-by-side, double-blind study. Br J Dermatol.May 2007;156(5):986-9. [Medline].
A 2008 study found botulinum toxin type A to be more effective thantopical 20% aluminum chloride for the treatment of moderate-to-severeprimary focal axillary hyperhidrosis.
在腋下多汗症的治療上,肉毒桿菌在多汗症的治療效果優於用擦的20%的局部止汗劑aluminum chloride。
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參考文獻
Flanagan KH, King R, Glaser DA. Botulinum toxin type a versustopical 20% aluminum chloride for the treatment of moderate to severeprimary focal axillary hyperhidrosis. J Drugs Dermatol. Mar2008;7(3):221-7. [Medline].
Woolery-Lloyd et al reported on successful treatment of inguinalhyperhidrosis with botulinum toxin A. The condition was initiallymisdiagnosis as urinary incontinence.
有學者用肉毒桿菌治療胯下多汗症,這個案例在最開始是被誤診為尿失禁。
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參考文獻
Woolery-Lloyd H, Elsaie ML, Avashia N. Inguinal hyperhidrosismisdiagnosed as urinary incontinence: treatment with botulinum toxin A.J Drugs Dermatol. Mar 2008;7(3):293-5. [Medline].